Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss

Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss

Objective: Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages. Thus, we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines. Patients and Study Des...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2005-10, Vol.90 (10), p.5876-5879
Hauptverfasser: Manigrasso, M. R., Ferroni, P., Santilli, F., Taraborelli, T., Guagnano, M. T., Michetti, N., Davì, G.
Format: Artikel
Sprache:eng
Schlagworte:
Adiponectin
Adult
Androgens - physiology
Biological and medical sciences
Blood Glucose - metabolism
Body Mass Index
Cross-Sectional Studies
Endocrinopathies
Energy Intake - physiology
Female
Fundamental and applied biological sciences. Psychology
Homeostasis - physiology
Humans
Intercellular Signaling Peptides and Proteins - blood
Interleukin-10 - blood
Medical sciences
Middle Aged
Obesity - blood
Vertebrates: endocrinology
Waist-Hip Ratio
Weight Loss - physiology
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Zusammenfassung:Objective: Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages. Thus, we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines. Patients and Study Design: Plasma adiponectin and IL-10 levels were analyzed in 64 android [body mass index (BMI), >28 kg/m2; waist to hip ratio (WHR), ≥0.86] and 20 gynoid [BMI, >28 kg/m2; WHR,
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2005-0281