Two New Triterpenoid Glycosides Isolated from Aesculus assamica GRIFF

Phytochemical study of the ethanol extract of the seeds of Aesculus assamica led to the isolation of two new triterpenoid saponins. The structure of the new compounds were elucidated on the basis of spectral data to be 28-O-acetyl-21-O-(4-O-angeloyl)-6-deoxy-β-glucopyranosyl-3-O-[β-glucopyranosyl(1—...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2005, Vol.53(10), pp.1310-1313
Hauptverfasser:	Liu, Hongwei, Zhang, Xue, Gao, Hao, Wang, Nali, Jin, Sanlin, Cai, Bin, Yao, Xinsheng, Cai, Guoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aesculus - chemistry Aesculus assamica Animals anti-fungal activity Carbohydrate Conformation Carbohydrate Sequence Cell Line, Tumor Cell Proliferation - drug effects cytotoxicity Drug Screening Assays, Antitumor Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans K562 Cells Microbial Sensitivity Tests Molecular Sequence Data Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Seeds - chemistry Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoid glycoside
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Zusammenfassung:	Phytochemical study of the ethanol extract of the seeds of Aesculus assamica led to the isolation of two new triterpenoid saponins. The structure of the new compounds were elucidated on the basis of spectral data to be 28-O-acetyl-21-O-(4-O-angeloyl)-6-deoxy-β-glucopyranosyl-3-O-[β-glucopyranosyl(1—2)-O-[β-glucopyranosyl(1—4)]-β-glucuronopyranosyl]protoaescigenin (1), and 21-O-(4-O-angeloyl)-6-deoxy-β-glucopyranosyl-3-O-[β-glucopyranosyl(1—2)-O-[β-glucopyranosyl(1—4)]-β-glucuronopyranosyl]protoaescigenin (2). Their in vitro bioactivity against plant pathogenic fungus Pyricularia oryzae and cytotoxicity against K562 and HCT-15 cell lines were evaluated.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.53.1310