Therapeutic strategies for the treatment of stroke

Acute ischaemic stroke is a major health problem with no effective treatments apart from the thrombolytic recombinant tissue plasminogen activator (rt-PA), which must be given within 3 h of stroke onset. However, rt-PA increases the risk of symptomatic intracranial haemorrhage and is administered to

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Bibliographische Detailangaben
Veröffentlicht in:	Drug discovery today 2006-08, Vol.11 (15), p.681-693
Hauptverfasser:	Green, A. Richard, Shuaib, Ashfaq
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzenesulfonates - therapeutic use Biological and medical sciences Cardiovascular Agents - therapeutic use Clinical Trials as Topic - methods Disease Models, Animal Humans Medical sciences Neuropharmacology Neuroprotective agent Nitrogen Oxides - therapeutic use Pharmacology. Drug treatments Stroke - drug therapy Stroke - physiopathology Thrombolytic Therapy - methods
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Beschreibung
Zusammenfassung:	Acute ischaemic stroke is a major health problem with no effective treatments apart from the thrombolytic recombinant tissue plasminogen activator (rt-PA), which must be given within 3 h of stroke onset. However, rt-PA increases the risk of symptomatic intracranial haemorrhage and is administered to
ISSN:	1359-6446 1878-5832
DOI:	10.1016/j.drudis.2006.06.001