Accelerating chemical replication steps of RNA involving activated ribonucleotides and downstream-binding elements

Accelerating chemical replication steps of RNA involving activated ribonucleotides and downstream-binding elements

Template-directed single nucleotide extension of an RNA primer with oxyazabenzotriazolides of ribonucleotides is shown to be fast and sequence-selective; downstream-binding RNA strands contribute to the acceleration of the reaction.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-10 (39), p.4922-4924
Hauptverfasser: Vogel, Stephanie R, Deck, Christopher, Richert, Clemens
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Hydrogen-Ion Concentration
Kinetics
Molecular Sequence Data
Ribonucleotides - chemistry
RNA - chemical synthesis
RNA - chemistry
Temperature
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Beschreibung
Zusammenfassung:Template-directed single nucleotide extension of an RNA primer with oxyazabenzotriazolides of ribonucleotides is shown to be fast and sequence-selective; downstream-binding RNA strands contribute to the acceleration of the reaction.
ISSN:1359-7345
1364-548X
DOI:10.1039/b510775j