Impact of body mass and body composition on circulating levels of natriuretic peptides : Results from the dallas heart study

The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue. To explore this association, we tested 2 hypotheses: (1) that N-terminal (NT)-proBNP,...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2005-10, Vol.112 (14), p.2163-2168
Hauptverfasser:	DAS, Sandeep R, DRAZNER, Mark H, DE LEMOS, James A, DRIES, Daniel L, VEGA, Gloria L, STANEK, Harold G, ABDULLAH, Shuaib M, CANHAM, Russell M, CHUNG, Anne K, LEONARD, David, WIANS, Frank H
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adult Aged Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body Composition Body Weight Cardiology. Vascular system Cardiovascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Humans Male Medical sciences Middle Aged Natriuretic Peptide, Brain - blood Obesity - blood Peptide Fragments - blood Pharmacology. Drug treatments Texas Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue. To explore this association, we tested 2 hypotheses: (1) that N-terminal (NT)-proBNP, which is not believed to bind NPR-C, would not be associated with BMI and (2) that lower BNP would be more closely associated with fat mass than with lean mass. Measurements of BNP, NT-proBNP, and body composition by direct dual energy x-ray absorptiometry (DEXA) were performed in 2707 subjects from the Dallas Heart Study. The associations between obesity and low BNP (
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.105.555573