Practical Synthesis of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]

Practical Synthesis of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]

An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2005, Vol.53(10), pp.1366-1368
Hauptverfasser: Tsutsui, Hideyuki, Abe, Takumi, Nakamura, Seiichi, Anada, Masahiro, Hashimoto, Shunichi
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
chiral catalyst
dirhodium(II) carboxylate
Leucine - analogs & derivatives
Leucine - chemical synthesis
Leucine - chemistry
Molecular Structure
N-phthaloylation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Rhodium - chemistry
Stereoisomerism
tert-leucine
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Beschreibung
Zusammenfassung:An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.1366