Pro-inflammatory cytokines in acute coronary syndromes: From bench to bedside

Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myoc...

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Veröffentlicht in:	Cytokine & growth factor reviews 2006-08, Vol.17 (4), p.225-233
Hauptverfasser:	Tousoulis, Dimitris, Antoniades, Charalambos, Koumallos, Nikolaos, Stefanadis, Christodoulos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Acute Disease Atherosclerosis - immunology Coronary Disease - diagnosis Coronary Disease - drug therapy Coronary Disease - immunology Cytokines Cytokines - antagonists & inhibitors Cytokines - metabolism Cytokines - physiology Humans Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Inflammation Mediators - physiology Myocardial Infarction - diagnosis Myocardial Infarction - immunology Plaque rupture Prognosis Syndrome
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Beschreibung
Zusammenfassung:	Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myocardial contractility and apoptosis. At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS.
ISSN:	1359-6101
DOI:	10.1016/j.cytogfr.2006.04.003