New concepts in the chromatography of peptides and proteins

Although chromatography using a variety of novel bed configurations (e.g. fluidized beds, expanded beds, simulated moving beds, annular rotating beds, etc.) has been of recent interest, the majority of practical applications of analytical and preparative chromatography employ a stationary adsorbent...

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Veröffentlicht in:Current opinion in biotechnology 2005-10, Vol.16 (5), p.552-560
Hauptverfasser: Frey, Douglas D, Kang, Xuezhen
Format: Artikel
Sprache:eng
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Zusammenfassung:Although chromatography using a variety of novel bed configurations (e.g. fluidized beds, expanded beds, simulated moving beds, annular rotating beds, etc.) has been of recent interest, the majority of practical applications of analytical and preparative chromatography employ a stationary adsorbent bed into which a feed slug is charged periodically, similar to the technique first described by Mikhail Tswett over 100 years ago. However, new concepts in both the practice and theory of fixed-bed chromatography are continuing to expand the available range of applications for separating peptides and proteins.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2005.07.004