Hyperdynamic Myocardial Response to Beta-Adrenergic Stimulation in Patients With Chest Pain and Normal Coronary Arteries

The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries. The mechanism of angina-like (AL) chest pain in patients with angiographically normal coronary ar...

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Veröffentlicht in:Journal of the American College of Cardiology 2005-10, Vol.46 (7), p.1270-1275
Hauptverfasser: Madaric, Juraj, Bartunek, Jozef, Verhamme, Katia, Penicka, Martin, Van Schuerbeeck, Eddy, Nellens, Paul, Heyndrickx, Guy R., Wijns, William, Vanderheyden, Marc, De Bruyne, Bernard
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Sprache:eng
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Zusammenfassung:The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries. The mechanism of angina-like (AL) chest pain in patients with angiographically normal coronary arteries remains controversial. Fifty-eight patients with AL pain and a normal coronary angiogram underwent dobutamine echocardiography (DE) to evaluate regional wall motion and intraventricular flow velocities (IFV). Control patients consisted of 22 matched patients free of angina and coronary artery disease. Abnormal IFV were defined as dagger-shaped Doppler spectrum ≥3 m/s. Dobutamine-induced regional wall motion abnormalities did not develop in any of the patients. An IFV ≥ 3 m/s was found in 28 patients (48%) with AL pain but in only 4 (18%) control patients (p < 0.05). In the subgroup of patients with AL pain and IFV ≥3 m/s, plasma renin concentration (PRC) was higher as compared with those with IFV
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2005.06.052