Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100® analyzer using bull blood.

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2005-09, Vol.40 (9), p.918-921
Hauptverfasser:	Ammazzalorso, Alessandra, Amoroso, Rosa, Baraldi, Mario, Bettoni, Giancarlo, Braghiroli, Daniela, De Filippis, Barbara, Giampietro, Letizia, Tricca, Maria L., Vezzalini, Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiplatelet activity Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cattle Clofibrate bioisosters Clofibric Acid - analogs & derivatives Clofibric Acid - chemical synthesis Clofibric Acid - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical Fibrates Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Medical sciences PFA-100 Pharmacology. Drug treatments Platelet Aggregation - drug effects Thiazoles - chemical synthesis Thiazoles - pharmacology Thioaryloxyacids
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Beschreibung
Zusammenfassung:	The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100® analyzer using bull blood.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2005.03.022