The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes
Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women. Methods In...
Gespeichert in:
| Veröffentlicht in: | Diabetic medicine 2006-07, Vol.23 (7), p.768-774 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 774 |
|---|---|
| container_issue | 7 |
| container_start_page | 768 |
| container_title | Diabetic medicine |
| container_volume | 23 |
| creator | Masding, M. G. Stears, A. J. Burdge, G. C. Wootton, S. A. Sandeman, D. D. |
| description | Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women.
Methods In a cross‐sectional study, fasting subjects [HRT+ and HRT– control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT–n = 14, control HRT+n = 7, control HRT–n = 11] consumed a meal containing the stable isotope 1,1,1–[13]C‐tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period.
Results In diabetic women, there were no differences between the HRT+ and HRT– groups for any of these parameters. In contrast, in HRT+ compared with HRT– control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT– 9.7 (3.9, 18.5) mmol/l per 6 h, P |
| doi_str_mv | 10.1111/j.1464-5491.2006.01867.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68638323</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68638323</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4357-6dc94be8a5fc5e61ab75a515b131a8bcc9df1de988b8a7159a4f0788bc52d4ad3</originalsourceid><addsrcrecordid>eNqNkMFu1DAQhi0EotvCKyBf4JZgx3bsHDig0hZQKUIscLQcZ0K9JHGws9rdt-mz8GQ4ZNVe8cUezfeP7Q8hTElO03q9ySkveSZ4RfOCkDInVJUy3z9Cq_vGY7QikhcZI5KeoNMYN4TQomLVU3RCS8ULrooViutbwDUM0LopYt9iD3EK_icMqRrw6OM0BjM0znS4c6NrcA-TqX3nYo9NANwlAruFzHoY_Gi2McE7nwq8c9MtXh9G-HNX4DSkhgniM_SkNV2E58f9DH27vFifv8-uP199OH97nVnOhMzKxla8BmVEawWU1NRSGEFFTRk1qra2alraQKVUrYykojK8JTJVVhQNNw07Q6-WuWPwv7fpX7p30ULXmQH8NupSlUyxgiVQLaANPsYArR6D6004aEr0LFxv9OxVz171LFz_E673KfrieMe27qF5CB4NJ-DlETDRmq5NMq2LD5ysKGdSJe7Nwu1cB4f_foB-9-liPqV8tuRdnGB_nzfhl05dKfSPmyv99fuXj4IIpjn7C8aXrgk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68638323</pqid></control><display><type>article</type><title>The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Masding, M. G. ; Stears, A. J. ; Burdge, G. C. ; Wootton, S. A. ; Sandeman, D. D.</creator><creatorcontrib>Masding, M. G. ; Stears, A. J. ; Burdge, G. C. ; Wootton, S. A. ; Sandeman, D. D.</creatorcontrib><description>Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women.
Methods In a cross‐sectional study, fasting subjects [HRT+ and HRT– control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT–n = 14, control HRT+n = 7, control HRT–n = 11] consumed a meal containing the stable isotope 1,1,1–[13]C‐tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period.
Results In diabetic women, there were no differences between the HRT+ and HRT– groups for any of these parameters. In contrast, in HRT+ compared with HRT– control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT– 9.7 (3.9, 18.5) mmol/l per 6 h, P < 0.05] and [13]C‐palmitic acid in the TG fraction was also lower [HRT+ 23.2 (10.3, 41.3) ng/ml per 6 h, HRT– 47.7 (12.6, 77.2) ng/ml per 6 h, P < 0.05], suggesting the lower postprandial triglyceridaemia associated with HRT in non‐diabetic women is because of better chylomicron clearance.
Conclusions The oestrogen‐associated advantage in clearance of dietary lipid we observed in non‐diabetic post‐menopausal women is not seen in post‐menopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of CVD protection seen in diabetic women.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2006.01867.x</identifier><identifier>PMID: 16842482</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Blood Glucose - analysis ; Cholesterol - blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Estrogen Replacement Therapy ; Estrogens - pharmacology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Nonesterified - blood ; Female ; Humans ; Insulin - blood ; lipoproteins ; Lipoproteins, HDL - blood ; Medical sciences ; Middle Aged ; oestrogens ; Palmitic Acid - blood ; Postmenopause - physiology ; postprandial ; Postprandial Period - physiology ; Triglycerides - blood ; Type 2 diabetes mellitus</subject><ispartof>Diabetic medicine, 2006-07, Vol.23 (7), p.768-774</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4357-6dc94be8a5fc5e61ab75a515b131a8bcc9df1de988b8a7159a4f0788bc52d4ad3</citedby><cites>FETCH-LOGICAL-c4357-6dc94be8a5fc5e61ab75a515b131a8bcc9df1de988b8a7159a4f0788bc52d4ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2006.01867.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2006.01867.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17914378$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16842482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masding, M. G.</creatorcontrib><creatorcontrib>Stears, A. J.</creatorcontrib><creatorcontrib>Burdge, G. C.</creatorcontrib><creatorcontrib>Wootton, S. A.</creatorcontrib><creatorcontrib>Sandeman, D. D.</creatorcontrib><title>The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women.
Methods In a cross‐sectional study, fasting subjects [HRT+ and HRT– control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT–n = 14, control HRT+n = 7, control HRT–n = 11] consumed a meal containing the stable isotope 1,1,1–[13]C‐tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period.
Results In diabetic women, there were no differences between the HRT+ and HRT– groups for any of these parameters. In contrast, in HRT+ compared with HRT– control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT– 9.7 (3.9, 18.5) mmol/l per 6 h, P < 0.05] and [13]C‐palmitic acid in the TG fraction was also lower [HRT+ 23.2 (10.3, 41.3) ng/ml per 6 h, HRT– 47.7 (12.6, 77.2) ng/ml per 6 h, P < 0.05], suggesting the lower postprandial triglyceridaemia associated with HRT in non‐diabetic women is because of better chylomicron clearance.
Conclusions The oestrogen‐associated advantage in clearance of dietary lipid we observed in non‐diabetic post‐menopausal women is not seen in post‐menopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of CVD protection seen in diabetic women.</description><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Cholesterol - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens - pharmacology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>lipoproteins</subject><subject>Lipoproteins, HDL - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>oestrogens</subject><subject>Palmitic Acid - blood</subject><subject>Postmenopause - physiology</subject><subject>postprandial</subject><subject>Postprandial Period - physiology</subject><subject>Triglycerides - blood</subject><subject>Type 2 diabetes mellitus</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EotvCKyBf4JZgx3bsHDig0hZQKUIscLQcZ0K9JHGws9rdt-mz8GQ4ZNVe8cUezfeP7Q8hTElO03q9ySkveSZ4RfOCkDInVJUy3z9Cq_vGY7QikhcZI5KeoNMYN4TQomLVU3RCS8ULrooViutbwDUM0LopYt9iD3EK_icMqRrw6OM0BjM0znS4c6NrcA-TqX3nYo9NANwlAruFzHoY_Gi2McE7nwq8c9MtXh9G-HNX4DSkhgniM_SkNV2E58f9DH27vFifv8-uP199OH97nVnOhMzKxla8BmVEawWU1NRSGEFFTRk1qra2alraQKVUrYykojK8JTJVVhQNNw07Q6-WuWPwv7fpX7p30ULXmQH8NupSlUyxgiVQLaANPsYArR6D6004aEr0LFxv9OxVz171LFz_E673KfrieMe27qF5CB4NJ-DlETDRmq5NMq2LD5ysKGdSJe7Nwu1cB4f_foB-9-liPqV8tuRdnGB_nzfhl05dKfSPmyv99fuXj4IIpjn7C8aXrgk</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Masding, M. G.</creator><creator>Stears, A. J.</creator><creator>Burdge, G. C.</creator><creator>Wootton, S. A.</creator><creator>Sandeman, D. D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes</title><author>Masding, M. G. ; Stears, A. J. ; Burdge, G. C. ; Wootton, S. A. ; Sandeman, D. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-6dc94be8a5fc5e61ab75a515b131a8bcc9df1de988b8a7159a4f0788bc52d4ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Cholesterol - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens - pharmacology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>lipoproteins</topic><topic>Lipoproteins, HDL - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>oestrogens</topic><topic>Palmitic Acid - blood</topic><topic>Postmenopause - physiology</topic><topic>postprandial</topic><topic>Postprandial Period - physiology</topic><topic>Triglycerides - blood</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masding, M. G.</creatorcontrib><creatorcontrib>Stears, A. J.</creatorcontrib><creatorcontrib>Burdge, G. C.</creatorcontrib><creatorcontrib>Wootton, S. A.</creatorcontrib><creatorcontrib>Sandeman, D. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masding, M. G.</au><au>Stears, A. J.</au><au>Burdge, G. C.</au><au>Wootton, S. A.</au><au>Sandeman, D. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2006-07</date><risdate>2006</risdate><volume>23</volume><issue>7</issue><spage>768</spage><epage>774</epage><pages>768-774</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women.
Methods In a cross‐sectional study, fasting subjects [HRT+ and HRT– control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT–n = 14, control HRT+n = 7, control HRT–n = 11] consumed a meal containing the stable isotope 1,1,1–[13]C‐tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period.
Results In diabetic women, there were no differences between the HRT+ and HRT– groups for any of these parameters. In contrast, in HRT+ compared with HRT– control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT– 9.7 (3.9, 18.5) mmol/l per 6 h, P < 0.05] and [13]C‐palmitic acid in the TG fraction was also lower [HRT+ 23.2 (10.3, 41.3) ng/ml per 6 h, HRT– 47.7 (12.6, 77.2) ng/ml per 6 h, P < 0.05], suggesting the lower postprandial triglyceridaemia associated with HRT in non‐diabetic women is because of better chylomicron clearance.
Conclusions The oestrogen‐associated advantage in clearance of dietary lipid we observed in non‐diabetic post‐menopausal women is not seen in post‐menopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of CVD protection seen in diabetic women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16842482</pmid><doi>10.1111/j.1464-5491.2006.01867.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-3071 |
| ispartof | Diabetic medicine, 2006-07, Vol.23 (7), p.768-774 |
| issn | 0742-3071 1464-5491 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68638323 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Blood Glucose - analysis Cholesterol - blood Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Estrogen Replacement Therapy Estrogens - pharmacology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Female Humans Insulin - blood lipoproteins Lipoproteins, HDL - blood Medical sciences Middle Aged oestrogens Palmitic Acid - blood Postmenopause - physiology postprandial Postprandial Period - physiology Triglycerides - blood Type 2 diabetes mellitus |
| title | The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T05%3A49%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20benefits%20of%20oestrogens%20on%20postprandial%20lipid%20metabolism%20are%20lost%20in%20post-menopausal%20women%20with%20Type%C2%A02%20diabetes&rft.jtitle=Diabetic%20medicine&rft.au=Masding,%20M.%20G.&rft.date=2006-07&rft.volume=23&rft.issue=7&rft.spage=768&rft.epage=774&rft.pages=768-774&rft.issn=0742-3071&rft.eissn=1464-5491&rft.coden=DIMEEV&rft_id=info:doi/10.1111/j.1464-5491.2006.01867.x&rft_dat=%3Cproquest_cross%3E68638323%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68638323&rft_id=info:pmid/16842482&rfr_iscdi=true |