The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes

Aims Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non‐diabetic and diabetic post‐menopausal women. Methods In a cross‐sectional study, fasting subjects [HRT+ and HRT– control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT–n = 14, control HRT+n = 7, control HRT–n = 11] consumed a meal containing the stable isotope 1,1,1–[13]C‐tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period. Results In diabetic women, there were no differences between the HRT+ and HRT– groups for any of these parameters. In contrast, in HRT+ compared with HRT– control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT– 9.7 (3.9, 18.5) mmol/l per 6 h, P