Valsartan Decreases Type I Collagen Synthesis in Patients With Hypertrophic Cardiomyopathy

Background Fibrosis, as well as myocyte hypertrophy, is the major determinant of prognosis in hypertrophic cardiomyopathy (HCM). Valsartan, an angiotensin II type 1 receptor blocker, may improve myocardial fibrosis in patients with HCM. Methods and Results Twenty-three patients with HCM were randoml...

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Veröffentlicht in:Circulation Journal 2005, Vol.69(10), pp.1244-1248
Hauptverfasser: Kawano, Hiroaki, Toda, Genji, Nakamizo, Reiichirou, Koide, Yuji, Seto, Shinji, Yano, Katsusuke
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Sprache:eng
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Zusammenfassung:Background Fibrosis, as well as myocyte hypertrophy, is the major determinant of prognosis in hypertrophic cardiomyopathy (HCM). Valsartan, an angiotensin II type 1 receptor blocker, may improve myocardial fibrosis in patients with HCM. Methods and Results Twenty-three patients with HCM were randomly divided into 2 groups: 11 patients had valsartan added to conventional treatment (V group) and 12 patients received the conventional therapy (C group). Plasma concentrations of brain natriuretic peptide (BNP), troponin T (TnT), aldosterone (ALDO), procollagen type I (PIP) and procollagen type III aminoterminal peptide (PIIINP) were measured before and 12 months after this study. Left ventricular wall thickness (LVWT) and ejection fraction (LVEF) were measured by echocardiography. PIP was decreased in the V group (123.2±63.1 ng/ml to 102.8±37.6, p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.69.1244