Total Synthesis of (−)-Scabronine G, an Inducer of Neurotrophic Factor Production

Total Synthesis of (−)-Scabronine G, an Inducer of Neurotrophic Factor Production

The total synthesis of (−)-scabronine G has been achieved in a concise manner from the (−)-Wieland−Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production.

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Veröffentlicht in:Journal of the American Chemical Society 2005-10, Vol.127 (39), p.13514-13515
Hauptverfasser: Waters, Stephen P, Tian, Yuan, Li, Yue-Ming, Danishefsky, Samuel J
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Chemistry
Diterpenes - chemical synthesis
Diterpenes - pharmacology
Exact sciences and technology
Nerve Growth Factors - biosynthesis
Organic chemistry
Preparations and properties
Terpenoids
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Zusammenfassung:The total synthesis of (−)-scabronine G has been achieved in a concise manner from the (−)-Wieland−Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja055220x