Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus

The objective of this study was to determine if early pregnancy maternal plasma lipid concentrations are elevated in women who later developed gestational diabetes mellitus (GDM) as compared with women who do not. Women, recruited prior to 16 weeks gestation, were followed until delivery. Maternal p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes research and clinical practice 2005-11, Vol.70 (2), p.134-142
Hauptverfasser: Enquobahrie, Daniel A., Williams, Michelle A., Qiu, Chunfang, Luthy, David A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 142
container_issue 2
container_start_page 134
container_title Diabetes research and clinical practice
container_volume 70
creator Enquobahrie, Daniel A.
Williams, Michelle A.
Qiu, Chunfang
Luthy, David A.
description The objective of this study was to determine if early pregnancy maternal plasma lipid concentrations are elevated in women who later developed gestational diabetes mellitus (GDM) as compared with women who do not. Women, recruited prior to 16 weeks gestation, were followed until delivery. Maternal plasma lipid concentrations were measured in samples collected at 13 weeks gestation on average. Generalized linear models were used to estimate relative risks (RR) and 95% confidence intervals (95% CI). 5.5% of the cohort (47/851) developed GDM. Elevated triglyceride (TG) was positively associated with GDM risk ( p for trend
doi_str_mv 10.1016/j.diabres.2005.03.022
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68631427</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822705001002</els_id><sourcerecordid>68631427</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-97d1a4f07a2e753dfadfee1608d485c4ca2ea3500daaf2a07da59e02bac24c6b3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoWqs_QcnJW9dJstndnkRK_YCCIHoO02S2pm53a7IV-u9NbcGjpwzJMzNvHsauBGQCRHG7zJzHeaCYSQCdgcpAyiM2EFUpR5WU5TEbJK76rc_YeYxLAChUrk_ZmShEVelSD9jrFEOz5etAixZbu-WNX3vHbddaavuAve_ayLF1vP8gHnz85F3NFxT73yds-C4G9RT5iprG95t4wU5qbCJdHs4he3-Yvk2eRrOXx-fJ_WxkVaH60bh0AvMaSpRUauVqdDWRKKByeaVtbtM9Kg3gEGuJUDrUYwI5RytzW8zVkN3s565D97VJiczKR5tCYEvdJpqiKpTIZZlAvQdt6GIMVJt18CsMWyPA7GSapTnINDuZBpRJMlPf9WHBZr4i99d1sJeAuz1A6ZvfnoKJ1lMy53wg2xvX-X9W_AAdlopn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68631427</pqid></control><display><type>article</type><title>Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Enquobahrie, Daniel A. ; Williams, Michelle A. ; Qiu, Chunfang ; Luthy, David A.</creator><creatorcontrib>Enquobahrie, Daniel A. ; Williams, Michelle A. ; Qiu, Chunfang ; Luthy, David A.</creatorcontrib><description>The objective of this study was to determine if early pregnancy maternal plasma lipid concentrations are elevated in women who later developed gestational diabetes mellitus (GDM) as compared with women who do not. Women, recruited prior to 16 weeks gestation, were followed until delivery. Maternal plasma lipid concentrations were measured in samples collected at 13 weeks gestation on average. Generalized linear models were used to estimate relative risks (RR) and 95% confidence intervals (95% CI). 5.5% of the cohort (47/851) developed GDM. Elevated triglyceride (TG) was positively associated with GDM risk ( p for trend &lt;0.001). After adjusting for maternal pre-pregnancy adiposity and other confounders, women with TG concentrations ≥137 mg/dl experienced a 3.5-fold increased risk of GDM (95% CI: 1.1–10.5) as compared with women who had concentrations &lt;96 mg/dl. We noted a linear component of trend in risk of GDM with increasing plasma TG. Each 20 mg/dl increase in TG was associated with a 10% increase in GDM risk (RR = 1.1; 95% CI: 1.0–1.3). Associations between GDM risk and plasma concentrations of other lipids (i.e., total cholesterol, high-density lipoprotein, and low-density lipoprotein) were not evident. Larger prospective studies are needed to confirm our findings and to identify modifiable determinants of pregnancy-associated dyslipidemia.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2005.03.022</identifier><identifier>PMID: 16188575</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Body Mass Index ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diabetes, Gestational - blood ; Diabetes, Gestational - physiopathology ; Dyslipidemias - blood ; Dyslipidemias - complications ; Dyslipidemias - physiopathology ; Female ; Gestational diabetes mellitus ; Humans ; Maternal Age ; Parity ; Plasma lipids ; Pregnancy ; Prospective Studies ; Risk Factors</subject><ispartof>Diabetes research and clinical practice, 2005-11, Vol.70 (2), p.134-142</ispartof><rights>2005 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-97d1a4f07a2e753dfadfee1608d485c4ca2ea3500daaf2a07da59e02bac24c6b3</citedby><cites>FETCH-LOGICAL-c363t-97d1a4f07a2e753dfadfee1608d485c4ca2ea3500daaf2a07da59e02bac24c6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2005.03.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16188575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enquobahrie, Daniel A.</creatorcontrib><creatorcontrib>Williams, Michelle A.</creatorcontrib><creatorcontrib>Qiu, Chunfang</creatorcontrib><creatorcontrib>Luthy, David A.</creatorcontrib><title>Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>The objective of this study was to determine if early pregnancy maternal plasma lipid concentrations are elevated in women who later developed gestational diabetes mellitus (GDM) as compared with women who do not. Women, recruited prior to 16 weeks gestation, were followed until delivery. Maternal plasma lipid concentrations were measured in samples collected at 13 weeks gestation on average. Generalized linear models were used to estimate relative risks (RR) and 95% confidence intervals (95% CI). 5.5% of the cohort (47/851) developed GDM. Elevated triglyceride (TG) was positively associated with GDM risk ( p for trend &lt;0.001). After adjusting for maternal pre-pregnancy adiposity and other confounders, women with TG concentrations ≥137 mg/dl experienced a 3.5-fold increased risk of GDM (95% CI: 1.1–10.5) as compared with women who had concentrations &lt;96 mg/dl. We noted a linear component of trend in risk of GDM with increasing plasma TG. Each 20 mg/dl increase in TG was associated with a 10% increase in GDM risk (RR = 1.1; 95% CI: 1.0–1.3). Associations between GDM risk and plasma concentrations of other lipids (i.e., total cholesterol, high-density lipoprotein, and low-density lipoprotein) were not evident. Larger prospective studies are needed to confirm our findings and to identify modifiable determinants of pregnancy-associated dyslipidemia.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - physiopathology</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - physiopathology</subject><subject>Female</subject><subject>Gestational diabetes mellitus</subject><subject>Humans</subject><subject>Maternal Age</subject><subject>Parity</subject><subject>Plasma lipids</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_QcnJW9dJstndnkRK_YCCIHoO02S2pm53a7IV-u9NbcGjpwzJMzNvHsauBGQCRHG7zJzHeaCYSQCdgcpAyiM2EFUpR5WU5TEbJK76rc_YeYxLAChUrk_ZmShEVelSD9jrFEOz5etAixZbu-WNX3vHbddaavuAve_ayLF1vP8gHnz85F3NFxT73yds-C4G9RT5iprG95t4wU5qbCJdHs4he3-Yvk2eRrOXx-fJ_WxkVaH60bh0AvMaSpRUauVqdDWRKKByeaVtbtM9Kg3gEGuJUDrUYwI5RytzW8zVkN3s565D97VJiczKR5tCYEvdJpqiKpTIZZlAvQdt6GIMVJt18CsMWyPA7GSapTnINDuZBpRJMlPf9WHBZr4i99d1sJeAuz1A6ZvfnoKJ1lMy53wg2xvX-X9W_AAdlopn</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Enquobahrie, Daniel A.</creator><creator>Williams, Michelle A.</creator><creator>Qiu, Chunfang</creator><creator>Luthy, David A.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus</title><author>Enquobahrie, Daniel A. ; Williams, Michelle A. ; Qiu, Chunfang ; Luthy, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-97d1a4f07a2e753dfadfee1608d485c4ca2ea3500daaf2a07da59e02bac24c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - physiopathology</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - physiopathology</topic><topic>Female</topic><topic>Gestational diabetes mellitus</topic><topic>Humans</topic><topic>Maternal Age</topic><topic>Parity</topic><topic>Plasma lipids</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enquobahrie, Daniel A.</creatorcontrib><creatorcontrib>Williams, Michelle A.</creatorcontrib><creatorcontrib>Qiu, Chunfang</creatorcontrib><creatorcontrib>Luthy, David A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enquobahrie, Daniel A.</au><au>Williams, Michelle A.</au><au>Qiu, Chunfang</au><au>Luthy, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>70</volume><issue>2</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>The objective of this study was to determine if early pregnancy maternal plasma lipid concentrations are elevated in women who later developed gestational diabetes mellitus (GDM) as compared with women who do not. Women, recruited prior to 16 weeks gestation, were followed until delivery. Maternal plasma lipid concentrations were measured in samples collected at 13 weeks gestation on average. Generalized linear models were used to estimate relative risks (RR) and 95% confidence intervals (95% CI). 5.5% of the cohort (47/851) developed GDM. Elevated triglyceride (TG) was positively associated with GDM risk ( p for trend &lt;0.001). After adjusting for maternal pre-pregnancy adiposity and other confounders, women with TG concentrations ≥137 mg/dl experienced a 3.5-fold increased risk of GDM (95% CI: 1.1–10.5) as compared with women who had concentrations &lt;96 mg/dl. We noted a linear component of trend in risk of GDM with increasing plasma TG. Each 20 mg/dl increase in TG was associated with a 10% increase in GDM risk (RR = 1.1; 95% CI: 1.0–1.3). Associations between GDM risk and plasma concentrations of other lipids (i.e., total cholesterol, high-density lipoprotein, and low-density lipoprotein) were not evident. Larger prospective studies are needed to confirm our findings and to identify modifiable determinants of pregnancy-associated dyslipidemia.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>16188575</pmid><doi>10.1016/j.diabres.2005.03.022</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0168-8227
ispartof Diabetes research and clinical practice, 2005-11, Vol.70 (2), p.134-142
issn 0168-8227
1872-8227
language eng
recordid cdi_proquest_miscellaneous_68631427
source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Adult
Body Mass Index
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes, Gestational - blood
Diabetes, Gestational - physiopathology
Dyslipidemias - blood
Dyslipidemias - complications
Dyslipidemias - physiopathology
Female
Gestational diabetes mellitus
Humans
Maternal Age
Parity
Plasma lipids
Pregnancy
Prospective Studies
Risk Factors
title Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T22%3A12%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20pregnancy%20lipid%20concentrations%20and%20the%20risk%20of%20gestational%20diabetes%20mellitus&rft.jtitle=Diabetes%20research%20and%20clinical%20practice&rft.au=Enquobahrie,%20Daniel%20A.&rft.date=2005-11-01&rft.volume=70&rft.issue=2&rft.spage=134&rft.epage=142&rft.pages=134-142&rft.issn=0168-8227&rft.eissn=1872-8227&rft_id=info:doi/10.1016/j.diabres.2005.03.022&rft_dat=%3Cproquest_cross%3E68631427%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68631427&rft_id=info:pmid/16188575&rft_els_id=S0168822705001002&rfr_iscdi=true