The effect of melatonin on sedation of children undergoing magnetic resonance imaging

Melatonin may induce a natural sleepiness and improve predictability of sedation drugs. We have investigated its clinical value in children sedated for magnetic resonance imaging. In a stratified randomized double-blind study, 98 children received either melatonin or placebo 10 min before they were...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2006-08, Vol.97 (2), p.220-225
Hauptverfasser:	Sury, M.R.J., Fairweather, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Anesthesia Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences brain brain, magnetic resonance imaging Capsules - analysis Child, Preschool Chloral Hydrate deep sedation Double-Blind Method Droperidol Drug Administration Schedule Female hormones hormones, melatonin Humans Hypnotics and Sedatives - administration & dosage Infant Magnetic Resonance Imaging Male Medical sciences melatonin Melatonin - administration & dosage paediatrics Pilot Projects sedation sedation, deep sedation Sleep - drug effects Temazepam Time Factors
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Beschreibung
Zusammenfassung:	Melatonin may induce a natural sleepiness and improve predictability of sedation drugs. We have investigated its clinical value in children sedated for magnetic resonance imaging. In a stratified randomized double-blind study, 98 children received either melatonin or placebo 10 min before they were sedated with a standard oral regimen. Children >5 and
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/ael144