Painful small-fiber neuropathy in Sjögren syndrome

Of 20 consecutive patients with Sjögren neuropathy, 16 (80%) presented with burning feet and 12 (60%) with non-length-dependent sensory symptoms. Leg and thigh skin biopsies, performed in 13 patients, including 7 with normal electrophysiology, showed either reduced epidermal nerve fiber (ENF) densit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2005-09, Vol.65 (6), p.925-927
Hauptverfasser:	CHAI, J, HERRMANN, D. N, STANTON, M, BARBANO, R. L, LOGIGIAN, E. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Antinuclear - immunology Autoantigens - immunology Axons - pathology Biological and medical sciences Biopsy Cell Size Complex syndromes Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Female Humans Male Medical genetics Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neural Conduction - immunology Neuralgia - diagnosis Neuralgia - etiology Neuralgia - physiopathology Neurology Peripheral Nerves - immunology Peripheral Nerves - pathology Peripheral Nerves - physiopathology Peripheral Nervous System Diseases - diagnosis Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - physiopathology Predictive Value of Tests Ribonucleoproteins - immunology Sensory Receptor Cells - pathology Sensory Receptor Cells - physiopathology Sjogren's Syndrome - diagnosis Sjogren's Syndrome - physiopathology Skin - innervation Skin - pathology SS-B Antigen
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Of 20 consecutive patients with Sjögren neuropathy, 16 (80%) presented with burning feet and 12 (60%) with non-length-dependent sensory symptoms. Leg and thigh skin biopsies, performed in 13 patients, including 7 with normal electrophysiology, showed either reduced epidermal nerve fiber (ENF) density or abnormal morphology. ENF loss was frequently non length dependent, suggesting that patients with this disorder commonly have a small-fiber sensory neuronopathy rather than a "dying-back" axonopathy.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000176034.38198.f9