A life course approach to cognitive reserve: A model for cognitive aging and development?

The concept of reserve in neuroscience maintains that there are aspects of brain structure and function that can buffer the effects of neuropathology such that the greater the reserve, the more severe the pathology must be to cause functional impairment. This article provides a concise overview of s...

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Veröffentlicht in:	Annals of neurology 2005-10, Vol.58 (4), p.617-622
Hauptverfasser:	Richards, Marcus, Deary, Ian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of Daily Living Aging - physiology Biological and medical sciences Cognition - physiology Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Human Development - physiology Humans Medical sciences Models, Biological Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuropsychological Tests Vertebrates: nervous system and sense organs
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Zusammenfassung:	The concept of reserve in neuroscience maintains that there are aspects of brain structure and function that can buffer the effects of neuropathology such that the greater the reserve, the more severe the pathology must be to cause functional impairment. This article provides a concise overview of structural and functional approaches to reserve and shows how reserve may be conceived as the sum of its lifetime input. In this context, reserve therefore provides an empirical yet general model of cognitive aging and development. Ann Neurol 2005;58:617–622
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.20637