Meroterpenes from the Ascidian Aplidium aff. densum

Chemical investigation of the ascidian Aplidium aff. densum collected at Masirah Island, Oman, has resulted in the isolation of five meroterpenes: two new ones, methoxyconidiol (1) and didehydroconicol (2), and three related, known compounds, 3-5. The structures of 1 and 2 were determined by a combi...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-09, Vol.68 (9), p.1412-1415
Hauptverfasser:	SIMON-LEVERT, Annabel, ARRAULT, Alban, BONTEMPS-SUBIELOS, Nataly, CANAL, Christophe, BANAIGS, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Aplidium Biological and medical sciences Escherichia coli - drug effects General aspects General pharmacology Humans Marine Medical sciences Micrococcus luteus - drug effects Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oman Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Staphylococcus - drug effects Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Tumor Cells, Cultured Urochordata - chemistry
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Zusammenfassung:	Chemical investigation of the ascidian Aplidium aff. densum collected at Masirah Island, Oman, has resulted in the isolation of five meroterpenes: two new ones, methoxyconidiol (1) and didehydroconicol (2), and three related, known compounds, 3-5. The structures of 1 and 2 were determined by a combination of mass spectrometry and one- and two-dimensional high-field NMR techniques. Their biological activities against bacteria and human lymphoblastic cell lines were evaluated.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050110p