N-Acetyldopamine Inhibits Rat Brain Lipid Peroxidation Induced by Lipopolysaccharide

: The effects of N‐acetyldopamine, a sepiapterin reductase inhibitor, on lipopolysaccharide‐induced lipid peroxidation were examined in rat brain homogenates in vitro. Lipid peroxidation in the form of malondialdehyde (MDA) was evaluated by the measurement of thiobarbituric acid (TBA) reactive subst...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-08, Vol.1053 (1), p.394-399
Hauptverfasser:	OXENKRUG, GREGORY F., REQUINTINA, PURA J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain Brain Chemistry - drug effects Dopamine - analogs & derivatives Dopamine - pharmacology Dose-Response Relationship, Drug Free Radical Scavengers - pharmacology lipid peroxidation Lipid Peroxidation - drug effects lipopolysaccharide Lipopolysaccharides - pharmacology malondialdehyde Melatonin - pharmacology N-acetyldopamine N-acetylserotonin Nerve Tissue Proteins - metabolism Oxidative Stress - drug effects Rats Rats, Inbred F344 sepiapterin reductase sepsis Thiobarbituric Acid Reactive Substances - metabolism
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Zusammenfassung:	: The effects of N‐acetyldopamine, a sepiapterin reductase inhibitor, on lipopolysaccharide‐induced lipid peroxidation were examined in rat brain homogenates in vitro. Lipid peroxidation in the form of malondialdehyde (MDA) was evaluated by the measurement of thiobarbituric acid (TBA) reactive substances. N‐Acetyldopamine inhibited the formation of MDA in a concentration‐dependent manner. The effect was similar to that of N‐acetylserotonin, but stronger than that of the endogenous antioxidant agent, melatonin. Possible clinical applications of N‐acetyldopamine and its derivatives are discussed.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2005.tb00047.x