Glycemic Status and Development of Kidney Disease: The Framingham Heart Study

OBJECTIVE:--Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. Whether pre-diabetes is associated with the development of kidney disease is unclear. RESEARCH DESIGN AND METHODS--Subjects free of chronic kidney disease...

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Veröffentlicht in:	Diabetes care 2005-10, Vol.28 (10), p.2436-2440
Hauptverfasser:	Fox, Caroline S, Larson, Martin G, Leip, Eric P, Meigs, James B, Wilson, Peter W.F, Levy, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cardiovascular disease Cardiovascular diseases Care and treatment Correlation analysis Diabetes Diabetes. Impaired glucose tolerance Diabetic Nephropathies - epidemiology Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Hyperglycemia - epidemiology Insulin Resistance Kidney diseases Longitudinal Studies Male Massachusetts - epidemiology Medical sciences Metabolic Syndrome - epidemiology Middle Aged Prediabetic State - epidemiology Renal Insufficiency, Chronic - epidemiology Risk Factors
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Zusammenfassung:	OBJECTIVE:--Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. Whether pre-diabetes is associated with the development of kidney disease is unclear. RESEARCH DESIGN AND METHODS--Subjects free of chronic kidney disease (CKD) were drawn from the Framingham Heart Study offspring cohort (1991-1995), given an oral glucose tolerance test, and followed for an average of 7 years for development of CKD (glomerular filtration rate [GFR] of
ISSN:	0149-5992 1935-5548
DOI:	10.2337/diacare.28.10.2436