Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis
The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be dis...
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| Veröffentlicht in: | Neurology 2005-09, Vol.65 (6), p.928-930 |
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| creator | SOMNIER, Finn E |
| description | The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors. |
| doi_str_mv | 10.1212/01.wnl.0000176067.32186.a3 |
| format | Article |
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The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.wnl.0000176067.32186.a3</identifier><identifier>PMID: 16186537</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Age Distribution ; Age of Onset ; Aged ; Aged, 80 and over ; Autoantibodies - blood ; Biological and medical sciences ; Denmark - epidemiology ; Diseases of striated muscles. Neuromuscular diseases ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Myasthenia Gravis - blood ; Myasthenia Gravis - epidemiology ; Myasthenia Gravis - immunology ; Neurology ; Neuromuscular Junction - immunology ; Neuromuscular Junction - physiopathology ; Receptors, Nicotinic - immunology ; Selection Bias ; Sex Distribution</subject><ispartof>Neurology, 2005-09, Vol.65 (6), p.928-930</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-f293ed6394bc7843d5023ae0827966c254795bf3acb87548e56cb06bd3059ffe3</citedby><cites>FETCH-LOGICAL-c413t-f293ed6394bc7843d5023ae0827966c254795bf3acb87548e56cb06bd3059ffe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17252263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16186537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOMNIER, Finn E</creatorcontrib><title>Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis</title><title>Neurology</title><addtitle>Neurology</addtitle><description>The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors.</description><subject>Age Distribution</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Denmark - epidemiology</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Myasthenia Gravis - blood</subject><subject>Myasthenia Gravis - epidemiology</subject><subject>Myasthenia Gravis - immunology</subject><subject>Neurology</subject><subject>Neuromuscular Junction - immunology</subject><subject>Neuromuscular Junction - physiopathology</subject><subject>Receptors, Nicotinic - immunology</subject><subject>Selection Bias</subject><subject>Sex Distribution</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtKAzEQhoMotlZfQRZB73bNYXNY70rxBAVBFLwL2exsG9lma7Kt9O2NWujczFx8_8zwIXRFcEEoobeYFN--K3AqIgUWsmCUKFEYdoTGhFORC0Y_jtEYY6pypqQaobMYPxPOqaxO0YiIxHMmx-j92dsAJjq_yJy3rgFvIevbrDMD5L2PMGTGDy6fzpavf1PdN7s8ixD6dR_d4LaQrXYmDkvwzmSLYLYunqOT1nQRLvZ9gt4f7t9mT_n85fF5Np3ntiRsyFtaMWgEq8raSlWyhmPKDGCVvhTCUl7KitctM7ZWkpcKuLA1FnXDMK_aFtgE3fzvXYf-awNx0CsXLXSd8dBvohZKUFLJKoF3_6ANfYwBWr0ObmXCThOsf6VqTHSSqg9S9Z9UbVgKX-6vbOoVNIfo3mICrveAidZ0bTDJZDxwknJKBWM_Ll2Bgw</recordid><startdate>20050927</startdate><enddate>20050927</enddate><creator>SOMNIER, Finn E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050927</creationdate><title>Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis</title><author>SOMNIER, Finn E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-f293ed6394bc7843d5023ae0827966c254795bf3acb87548e56cb06bd3059ffe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Distribution</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Denmark - epidemiology</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Myasthenia Gravis - blood</topic><topic>Myasthenia Gravis - epidemiology</topic><topic>Myasthenia Gravis - immunology</topic><topic>Neurology</topic><topic>Neuromuscular Junction - immunology</topic><topic>Neuromuscular Junction - physiopathology</topic><topic>Receptors, Nicotinic - immunology</topic><topic>Selection Bias</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOMNIER, Finn E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOMNIER, Finn E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2005-09-27</date><risdate>2005</risdate><volume>65</volume><issue>6</issue><spage>928</spage><epage>930</epage><pages>928-930</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16186537</pmid><doi>10.1212/01.wnl.0000176067.32186.a3</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 2005-09, Vol.65 (6), p.928-930 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Age Distribution Age of Onset Aged Aged, 80 and over Autoantibodies - blood Biological and medical sciences Denmark - epidemiology Diseases of striated muscles. Neuromuscular diseases Female Humans Incidence Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myasthenia Gravis - blood Myasthenia Gravis - epidemiology Myasthenia Gravis - immunology Neurology Neuromuscular Junction - immunology Neuromuscular Junction - physiopathology Receptors, Nicotinic - immunology Selection Bias Sex Distribution |
| title | Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis |
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