Increasing incidence of late-onset anti-AChR antibody- seropositive myasthenia gravis

The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be dis...

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Veröffentlicht in:Neurology 2005-09, Vol.65 (6), p.928-930
1. Verfasser: SOMNIER, Finn E
Format: Artikel
Sprache:eng
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Zusammenfassung:The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors.
ISSN:0028-3878
1526-632X
DOI:10.1212/01.wnl.0000176067.32186.a3