Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents

7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activ...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-08, Vol.14 (16), p.5678-5682
Hauptverfasser:	BHAWANI SINGH RATHORE, KUMAR, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Aspergillus - drug effects Bacillus - drug effects Biological and medical sciences Cyclization Dimethyl Sulfoxide - chemistry Escherichia coli - drug effects Esters - chemistry Fluorobenzenes - chemistry General aspects Ketones - chemistry Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Phenols - chemistry Structure-Activity Relationship Sulfhydryl Compounds - chemistry Thiazines - chemical synthesis Thiazines - pharmacology
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Zusammenfassung:	7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2006.04.009