Altered nociceptive response in ADAM11-deficient mice

Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM1...

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Veröffentlicht in:	Brain research 2006-06, Vol.1097 (1), p.39-42
Hauptverfasser:	Takahashi, Eiki, Sagane, Koji, Nagasu, Takeshi, Kuromitsu, Junro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid writhing test ADAM Proteins - deficiency ADAM Proteins - genetics ADAM Proteins - physiology ADAM11 ADAM11-deficient mice Animals Biological and medical sciences Formalin paw test Fundamental and applied biological sciences. Psychology Hot plate test Male Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Nociceptive transmission Pain - genetics Pain - metabolism Pain Measurement - methods Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs Von Frey test
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Zusammenfassung:	Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2006.04.043