A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning

An interface to allow on‐line qualitative and quantitative full‐plate detection and analysis of compounds separated by thin‐layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes an...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2005-01, Vol.19 (19), p.2789-2793
Hauptverfasser:	Peng, Song, Edler, Michael, Ahlmann, Norman, Hoffmann, Thorsten, Franzke, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Atmospheric Pressure Chromatography - instrumentation Chromatography - methods Equipment Design Equipment Failure Analysis Specimen Handling - instrumentation Specimen Handling - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Systems Integration
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Beschreibung
Zusammenfassung:	An interface to allow on‐line qualitative and quantitative full‐plate detection and analysis of compounds separated by thin‐layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:	0951-4198 1097-0231
DOI:	10.1002/rcm.2120