Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

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Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2005-10, Vol.19 (10), p.1851-1853
Hauptverfasser:	Hamzah, H G, Pierce, A, Stewart, W A, Peter Downes, C, Gray, A, Irvine, A, Spooncer, E, Whetton, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - metabolism Benzamides Cancer Research CD34 antigen Chemotactic factors Chemotactic Factors - pharmacology Chronic myeloid leukemia correspondence Critical Care Medicine Cytokines Cytokines - pharmacology Hematology Humans Imatinib Imatinib Mesylate Intensive Internal Medicine Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Lymphocytes - metabolism Medicine Medicine & Public Health Myeloid leukemia Oncology Phosphatidylinositol Phosphatidylinositol Phosphates - metabolism Piperazines - therapeutic use Pyrimidines - therapeutic use
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