Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-Dependent Mycobacterium tuberculosis Strain 18b

Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study sugges...

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Veröffentlicht in:	Infection and Immunity 2005-10, Vol.73 (10), p.7051-7055
Hauptverfasser:	Fukasawa, Yutaka, Kawamura, Ikuo, Uchiyama, Ryosuke, Yamamoto, Kazuhiro, Kaku, Taijin, Tominaga, Takanari, Nomura, Takamasa, Ichiyama, Satoshi, Ezaki, Takayuki, Mitsuyama, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Cytokines - metabolism Fundamental and applied biological sciences. Psychology Mice Microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Streptomycin - pharmacology Tuberculosis - immunology
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Zusammenfassung:	Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.10.7051-7055.2005