Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl

Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5‐year‐old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presen...

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Veröffentlicht in:	Pediatric Blood & Cancer 2005-11, Vol.45 (6), p.846-849
Hauptverfasser:	Masjosthusmann, Katja, Bielack, Stefan S., Köhler, Gabriele, Florax, Annekathrein, Schiborr, Manfred, Bruch, Jochen, Reinhardt, Dirk, Kuhn, Nanna, Paulussen, Michael, Jürgens, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukemia Biological and medical sciences Child, Preschool Combined Modality Therapy Core Binding Factor Alpha 2 Subunit Disease-Free Survival Ewing sarcoma Female General aspects Humans Medical sciences Oncogene Proteins, Fusion Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Proto-Oncogene Protein c-fli-1 RNA-Binding Protein EWS Sarcoma, Ewing - complications Sarcoma, Ewing - diagnosis Sarcoma, Ewing - therapy secondary neoplasms translocation Translocation, Genetic Tumors
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Zusammenfassung:	Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5‐year‐old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT‐PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis. Pediatr Blood Cancer © 2005 Wiley‐Liss, Inc.
ISSN:	1545-5009 1545-5017 1096-911X
DOI:	10.1002/pbc.20265