Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues

Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues

Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally o...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-09, Vol.44 (37), p.5989-5992
Hauptverfasser: Sessler, Jonathan L., Eller, Leah R., Cho, Won-Seob, Nicolaou, Sergios, Aguilar, Apolonio, Lee, Jeong Tae, Lynch, Vincent M., Magda, Darren J.
Format: Artikel
Sprache:eng
Schlagworte:
Anions - metabolism
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Crystallography, X-Ray
Humans
ion transport
membranes
molecular recognition
nitrogen heterocycles
prodigiosin
Prodigiosin - chemistry
Prodigiosin - metabolism
Prodigiosin - pharmacology
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Beschreibung
Zusammenfassung:Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally occurring pigment (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200501740