ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1–7)

The discovery of angiotensin-converting enzyme 2 (ACE-2) has revealed a far more complex enzymatic cascade that may influence the renin-angiotensin system within the kidney, specifically the expression of the functional products angiotensin II (Ang II) and Ang-(1-7). The regulation of this critical...

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Veröffentlicht in:	Kidney international 2006-07, Vol.70 (1), p.8-10
Hauptverfasser:	Chappel, M.C., Ferrario, C.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - metabolism Angiotensin II - metabolism Animals Blood Pressure - genetics Blood Pressure - physiology Hypertension - genetics Hypertension - metabolism Peptide Fragments - metabolism Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - physiology Rats Rats, Inbred Strains
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Beschreibung
Zusammenfassung:	The discovery of angiotensin-converting enzyme 2 (ACE-2) has revealed a far more complex enzymatic cascade that may influence the renin-angiotensin system within the kidney, specifically the expression of the functional products angiotensin II (Ang II) and Ang-(1-7). The regulation of this critical system involved in blood pressure control must now encompass the integral relationship of ACE and ACE-2 activities.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/sj.ki.5000321