p47phox-Dependent NADPH Oxidase Regulates Flow-Induced Vascular Remodeling

Chronic alterations in blood flow elicit an adaptive response that tends to normalize shear stress, involving nitric oxide (NO) and matrix metalloproteinases (MMPs). To evaluate the role of NADPH oxidase in this process, we developed a new model of mouse arteriovenous fistula (AVF) connecting the ri...

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Veröffentlicht in:	Circulation research 2005-09, Vol.97 (6), p.533-540
Hauptverfasser:	Castier, Yves, Brandes, Ralf P, Leseche, Guy, Tedgui, Alain, Lehoux, Stéphanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carotid Artery, Common - pathology Fundamental and applied biological sciences. Psychology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL NADPH Oxidase 2 NADPH Oxidases - physiology Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Phosphoproteins - physiology Reactive Oxygen Species Regional Blood Flow Stress, Mechanical Vertebrates: cardiovascular system
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Zusammenfassung:	Chronic alterations in blood flow elicit an adaptive response that tends to normalize shear stress, involving nitric oxide (NO) and matrix metalloproteinases (MMPs). To evaluate the role of NADPH oxidase in this process, we developed a new model of mouse arteriovenous fistula (AVF) connecting the right common carotid artery (RCCA) with the jugular vein, which does not affect blood pressure. Mice deficient for gp91phox and p47phox subunits of NADPH and wild-type controls were used. AVF greatly increased RCCA blood flow (0.78±0.12 to 4.71±0.78 mL/min; P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.0000181759.63239.21