Impaired spatial learning in a novel rat model of mild cerebral concussion injury

The aim of the present study was to develop a model of mild traumatic brain injury in the rat that mimics human concussive brain injury suitable to study pathophysiology and potential treatments. 34 male Wistar rats received a closed head trauma (TBI) and 30 animals served as controls (CON). Immedia...

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Veröffentlicht in:	Experimental neurology 2005-10, Vol.195 (2), p.447-457
Hauptverfasser:	Henninger, Nils, Dützmann, Stephan, Sicard, Kenneth M., Kollmar, Rainer, Bardutzky, Jürgen, Schwab, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	ADC Analysis of Variance Animal model Animals Behavior, Animal Biological and medical sciences Blood Pressure - physiology Brain - metabolism Brain - pathology Brain - physiopathology Brain Concussion - complications Brain Concussion - metabolism Brain Concussion - pathology Cell Count - methods Cell Death Diffuse axonal injury Disease Models, Animal DWI Heart Rate - physiology Histology Immunohistochemistry - methods Injuries of the nervous system and the skull. Diseases due to physical agents Learning Disabilities - etiology Learning Disabilities - metabolism Learning Disabilities - pathology Magnetic Resonance Imaging - methods Male MAP-2 Maze Learning - physiology Medical sciences Microtubule-Associated Proteins - metabolism Morris water maze MRI Neurology Rats Rats, Wistar Spatial Behavior - physiology Time Factors Traumas. Diseases due to physical agents Traumatic brain injury Vascular diseases and vascular malformations of the nervous system βAPP
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Zusammenfassung:	The aim of the present study was to develop a model of mild traumatic brain injury in the rat that mimics human concussive brain injury suitable to study pathophysiology and potential treatments. 34 male Wistar rats received a closed head trauma (TBI) and 30 animals served as controls (CON). Immediately following trauma, animals lost their muscle tone and righting reflex response, recovering from the latter within 11.4 ± 8.2 min. Corneal reflex and whisker responses returned within 4.5 ± 3.0 min and 6.1 ± 2.9 min, respectively. The impact resulted in a short transient decrease of pO 2 ( P
ISSN:	0014-4886 1090-2430
DOI:	10.1016/j.expneurol.2005.06.013