Solid/Solution-Phase Annulation Reagents: Single-Step Synthesis of Cyclic Amine Derivatives

Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine‐derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure–activity relationships.