Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids
In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulat...
Gespeichert in:
| Veröffentlicht in: | Lipids 2006-04, Vol.41 (4), p.341-346 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 346 |
|---|---|
| container_issue | 4 |
| container_start_page | 341 |
| container_title | Lipids |
| container_volume | 41 |
| creator | Bitsanis, Demetris Ghebremeskel, Kebreab Moodley, Therishnee Crawford, Michael A Djahanbakhch, Ovrang |
| description | In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulation by the placenta, we have investigated whether the FA composition of the placenta is altered by GDM. Thirty-six women, 11 with and 25 without GDM, were recruited from Newham General Hospital, London. The women with GDM had higher levels of di-homo-γ-linolenic (P |
| doi_str_mv | 10.1007/s11745-006-5104-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68587108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1073652751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4641-ab421ad49689b983cb3358d99cf03b4dd478d8621effd2730660a3c764219dd73</originalsourceid><addsrcrecordid>eNqFkcGL1TAQxoMo7nP1D_CixYO36qRJk_Qoq64LDxR0z2GapPuy9CW1adH9751HHwhePISQye_7mJmPsZcc3nEA_b5wrmVbA6i65SBr84jteNuauhOgH7MdQCNr2QC_YM9Kuacnl137lF1wZcBwqXfs7jqUBZeYE46Vj9iHJZTqGMYxLmupQjpgclTBGd0h-pyiqzD5ymeXCx7Cbwwpn2ou-lLFVE0jupAWcpsOudAZ40Rfz9mTAccSXpzvS3b7-dOPqy_1_uv1zdWHfe2kkrzGXjYcveyU6frOCNcL0RrfdW4A0UvvpTbeqIaHYfCNFqAUoHBakazzXotL9nbzneb8c6XZ7DEWR-NgCnktVpnWaA6GwDf_gPd5nWkLxTaaejGqBYL4Brk5lzKHwU5zPOL8YDnYUwR2i8BSBPYUgT0Zvzobr_0x-L-K884J0BvwK47h4f-Odn_z7SMIyUn5elMOmC3ezbHY2-8UryCdpKmE-AMrrJvK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274648650</pqid></control><display><type>article</type><title>Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals</source><creator>Bitsanis, Demetris ; Ghebremeskel, Kebreab ; Moodley, Therishnee ; Crawford, Michael A ; Djahanbakhch, Ovrang</creator><creatorcontrib>Bitsanis, Demetris ; Ghebremeskel, Kebreab ; Moodley, Therishnee ; Crawford, Michael A ; Djahanbakhch, Ovrang</creatorcontrib><description><![CDATA[In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulation by the placenta, we have investigated whether the FA composition of the placenta is altered by GDM. Thirty-six women, 11 with and 25 without GDM, were recruited from Newham General Hospital, London. The women with GDM had higher levels of di-homo-γ-linolenic (P<0.05), docosate-traenoic (n-6 DTA; P<0.0001), docosapentaenoic n-6 (P<0.005), total n-6 (P<0.005), docosapentaenoic (n-3 DPA; P<0.005), and total n-3 (P<0.01) FA, as well as higher levels of AA (P<0.05) and DHA (P<0.01), in placental choline phosphoglycerides (CPG) compared with the healthy women who served as controls. Similarly, the women with GDM had elevated n-6 DTA (P<0.005), AA, total n-6 metabolites (P<0.05), DHA, total n-3 metabolites, and total n-3 FA (P<0.005) in ethanolamine phosphoglycerides (EPG). In contrast to CPG and EPG, the placental TG of the women with GDM had higher linoleic acid (P<0.05) and lower AA, n-6 metabolites, and n-3 DPA (P<0.01). The placenta is devoid of desaturase activity, and it is thought to be reliant on maternal circulation for both AA and DHA. Hence, the enhanced levels of the two FA in the placenta of the GDM group suggests that these FA are taken up from the maternal circulation and retained after esterification into phosphoglycerides instead of being transferred to the fetus. Further study is needed to elucidate the mechanism involved and the effect of the phenomenon on postnatal growth and development of the offspring.]]></description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-006-5104-8</identifier><identifier>PMID: 16808147</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Arachidonic Acid - metabolism ; Case-Control Studies ; Diabetes, Gestational - metabolism ; Diabetes, Gestational - pathology ; Docosahexaenoic Acids - metabolism ; Ethanolamine - metabolism ; Fatty Acids - metabolism ; Female ; Glycerophospholipids - metabolism ; Humans ; Metabolites ; Neonates ; Offspring ; Organ Size ; Phospholipids - metabolism ; Placenta - chemistry ; Placenta - metabolism ; Pregnancy</subject><ispartof>Lipids, 2006-04, Vol.41 (4), p.341-346</ispartof><rights>2006 American Oil Chemists' Society (AOCS)</rights><rights>Copyright AOCS Press Apr 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4641-ab421ad49689b983cb3358d99cf03b4dd478d8621effd2730660a3c764219dd73</citedby><cites>FETCH-LOGICAL-c4641-ab421ad49689b983cb3358d99cf03b4dd478d8621effd2730660a3c764219dd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-006-5104-8$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-006-5104-8$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16808147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bitsanis, Demetris</creatorcontrib><creatorcontrib>Ghebremeskel, Kebreab</creatorcontrib><creatorcontrib>Moodley, Therishnee</creatorcontrib><creatorcontrib>Crawford, Michael A</creatorcontrib><creatorcontrib>Djahanbakhch, Ovrang</creatorcontrib><title>Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids</title><title>Lipids</title><addtitle>Lipids</addtitle><description><![CDATA[In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulation by the placenta, we have investigated whether the FA composition of the placenta is altered by GDM. Thirty-six women, 11 with and 25 without GDM, were recruited from Newham General Hospital, London. The women with GDM had higher levels of di-homo-γ-linolenic (P<0.05), docosate-traenoic (n-6 DTA; P<0.0001), docosapentaenoic n-6 (P<0.005), total n-6 (P<0.005), docosapentaenoic (n-3 DPA; P<0.005), and total n-3 (P<0.01) FA, as well as higher levels of AA (P<0.05) and DHA (P<0.01), in placental choline phosphoglycerides (CPG) compared with the healthy women who served as controls. Similarly, the women with GDM had elevated n-6 DTA (P<0.005), AA, total n-6 metabolites (P<0.05), DHA, total n-3 metabolites, and total n-3 FA (P<0.005) in ethanolamine phosphoglycerides (EPG). In contrast to CPG and EPG, the placental TG of the women with GDM had higher linoleic acid (P<0.05) and lower AA, n-6 metabolites, and n-3 DPA (P<0.01). The placenta is devoid of desaturase activity, and it is thought to be reliant on maternal circulation for both AA and DHA. Hence, the enhanced levels of the two FA in the placenta of the GDM group suggests that these FA are taken up from the maternal circulation and retained after esterification into phosphoglycerides instead of being transferred to the fetus. Further study is needed to elucidate the mechanism involved and the effect of the phenomenon on postnatal growth and development of the offspring.]]></description><subject>Adult</subject><subject>Arachidonic Acid - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diabetes, Gestational - pathology</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Ethanolamine - metabolism</subject><subject>Fatty Acids - metabolism</subject><subject>Female</subject><subject>Glycerophospholipids - metabolism</subject><subject>Humans</subject><subject>Metabolites</subject><subject>Neonates</subject><subject>Offspring</subject><subject>Organ Size</subject><subject>Phospholipids - metabolism</subject><subject>Placenta - chemistry</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcGL1TAQxoMo7nP1D_CixYO36qRJk_Qoq64LDxR0z2GapPuy9CW1adH9751HHwhePISQye_7mJmPsZcc3nEA_b5wrmVbA6i65SBr84jteNuauhOgH7MdQCNr2QC_YM9Kuacnl137lF1wZcBwqXfs7jqUBZeYE46Vj9iHJZTqGMYxLmupQjpgclTBGd0h-pyiqzD5ymeXCx7Cbwwpn2ou-lLFVE0jupAWcpsOudAZ40Rfz9mTAccSXpzvS3b7-dOPqy_1_uv1zdWHfe2kkrzGXjYcveyU6frOCNcL0RrfdW4A0UvvpTbeqIaHYfCNFqAUoHBakazzXotL9nbzneb8c6XZ7DEWR-NgCnktVpnWaA6GwDf_gPd5nWkLxTaaejGqBYL4Brk5lzKHwU5zPOL8YDnYUwR2i8BSBPYUgT0Zvzobr_0x-L-K884J0BvwK47h4f-Odn_z7SMIyUn5elMOmC3ezbHY2-8UryCdpKmE-AMrrJvK</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Bitsanis, Demetris</creator><creator>Ghebremeskel, Kebreab</creator><creator>Moodley, Therishnee</creator><creator>Crawford, Michael A</creator><creator>Djahanbakhch, Ovrang</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids</title><author>Bitsanis, Demetris ; Ghebremeskel, Kebreab ; Moodley, Therishnee ; Crawford, Michael A ; Djahanbakhch, Ovrang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4641-ab421ad49689b983cb3358d99cf03b4dd478d8621effd2730660a3c764219dd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Arachidonic Acid - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diabetes, Gestational - pathology</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>Ethanolamine - metabolism</topic><topic>Fatty Acids - metabolism</topic><topic>Female</topic><topic>Glycerophospholipids - metabolism</topic><topic>Humans</topic><topic>Metabolites</topic><topic>Neonates</topic><topic>Offspring</topic><topic>Organ Size</topic><topic>Phospholipids - metabolism</topic><topic>Placenta - chemistry</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bitsanis, Demetris</creatorcontrib><creatorcontrib>Ghebremeskel, Kebreab</creatorcontrib><creatorcontrib>Moodley, Therishnee</creatorcontrib><creatorcontrib>Crawford, Michael A</creatorcontrib><creatorcontrib>Djahanbakhch, Ovrang</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bitsanis, Demetris</au><au>Ghebremeskel, Kebreab</au><au>Moodley, Therishnee</au><au>Crawford, Michael A</au><au>Djahanbakhch, Ovrang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2006-04</date><risdate>2006</risdate><volume>41</volume><issue>4</issue><spage>341</spage><epage>346</epage><pages>341-346</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract><![CDATA[In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulation by the placenta, we have investigated whether the FA composition of the placenta is altered by GDM. Thirty-six women, 11 with and 25 without GDM, were recruited from Newham General Hospital, London. The women with GDM had higher levels of di-homo-γ-linolenic (P<0.05), docosate-traenoic (n-6 DTA; P<0.0001), docosapentaenoic n-6 (P<0.005), total n-6 (P<0.005), docosapentaenoic (n-3 DPA; P<0.005), and total n-3 (P<0.01) FA, as well as higher levels of AA (P<0.05) and DHA (P<0.01), in placental choline phosphoglycerides (CPG) compared with the healthy women who served as controls. Similarly, the women with GDM had elevated n-6 DTA (P<0.005), AA, total n-6 metabolites (P<0.05), DHA, total n-3 metabolites, and total n-3 FA (P<0.005) in ethanolamine phosphoglycerides (EPG). In contrast to CPG and EPG, the placental TG of the women with GDM had higher linoleic acid (P<0.05) and lower AA, n-6 metabolites, and n-3 DPA (P<0.01). The placenta is devoid of desaturase activity, and it is thought to be reliant on maternal circulation for both AA and DHA. Hence, the enhanced levels of the two FA in the placenta of the GDM group suggests that these FA are taken up from the maternal circulation and retained after esterification into phosphoglycerides instead of being transferred to the fetus. Further study is needed to elucidate the mechanism involved and the effect of the phenomenon on postnatal growth and development of the offspring.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>16808147</pmid><doi>10.1007/s11745-006-5104-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 2006-04, Vol.41 (4), p.341-346 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68587108 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SpringerLink Journals |
| subjects | Adult Arachidonic Acid - metabolism Case-Control Studies Diabetes, Gestational - metabolism Diabetes, Gestational - pathology Docosahexaenoic Acids - metabolism Ethanolamine - metabolism Fatty Acids - metabolism Female Glycerophospholipids - metabolism Humans Metabolites Neonates Offspring Organ Size Phospholipids - metabolism Placenta - chemistry Placenta - metabolism Pregnancy |
| title | Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T06%3A43%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gestational%20diabetes%20mellitus%20enhances%20arachidonic%20and%20docosahexaenoic%20acids%20in%20placental%20phospholipids&rft.jtitle=Lipids&rft.au=Bitsanis,%20Demetris&rft.date=2006-04&rft.volume=41&rft.issue=4&rft.spage=341&rft.epage=346&rft.pages=341-346&rft.issn=0024-4201&rft.eissn=1558-9307&rft_id=info:doi/10.1007/s11745-006-5104-8&rft_dat=%3Cproquest_cross%3E1073652751%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=274648650&rft_id=info:pmid/16808147&rfr_iscdi=true |