Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids

Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids

In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulat...

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Veröffentlicht in:Lipids 2006-04, Vol.41 (4), p.341-346
Hauptverfasser: Bitsanis, Demetris, Ghebremeskel, Kebreab, Moodley, Therishnee, Crawford, Michael A, Djahanbakhch, Ovrang
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Arachidonic Acid - metabolism
Case-Control Studies
Diabetes, Gestational - metabolism
Diabetes, Gestational - pathology
Docosahexaenoic Acids - metabolism
Ethanolamine - metabolism
Fatty Acids - metabolism
Female
Glycerophospholipids - metabolism
Humans
Metabolites
Neonates
Offspring
Organ Size
Phospholipids - metabolism
Placenta - chemistry
Placenta - metabolism
Pregnancy
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Zusammenfassung:In previous studies, we reported that neonates of women with gestational diabetes mellitus (GDM) have reduced blood levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) that were unrelated to maternal status. Since both AA and DHA are selectively transferred from maternal to fetal circulation by the placenta, we have investigated whether the FA composition of the placenta is altered by GDM. Thirty-six women, 11 with and 25 without GDM, were recruited from Newham General Hospital, London. The women with GDM had higher levels of di-homo-γ-linolenic (P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-006-5104-8