Translational control during mitosis

Translation is now recognized as an important process in the regulation of gene expression. During the cell cycle, translation is tightly regulated. Protein synthesis is necessary for entry into and progression through mitosis and conversely, modifications of translational activity are observed duri...

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Veröffentlicht in:	Biochimie 2005-09, Vol.87 (9), p.805-811
Hauptverfasser:	Le Breton, Magali, Cormier, Patrick, Bellé, Robert, Mulner-Lorillon, Odile, Morales, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	CDC2 Protein Kinase - metabolism CDK1 Cell Cycle - genetics Cyclin B - metabolism Cyclin B complex Cyclin B1 G2 Phase - genetics G2 Phase - physiology Gene Expression Regulation Mitosis Mitosis - genetics Mitosis - physiology Phosphorylation Polyadenylation Protein Biosynthesis RNA, Messenger - metabolism Translation
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Beschreibung
Zusammenfassung:	Translation is now recognized as an important process in the regulation of gene expression. During the cell cycle, translation is tightly regulated. Protein synthesis is necessary for entry into and progression through mitosis and conversely, modifications of translational activity are observed during the cell cycle. This review focuses on translational control during mitosis (or M-phase) and the role of CDK1/cyclin B, the universal cell cycle regulator implicated in the G2/M transition, in protein synthesis regulation.
ISSN:	0300-9084 1638-6183
DOI:	10.1016/j.biochi.2005.04.014