The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. II. Biological activities

The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. II. Biological activities

The novel gluconeogenesis inhibitor FR225654, isolated from the culture broth of Phoma sp. No. 00144, has an unique structure that consists of a highly oxygenated trans-decalin ring and a beta-keto-enol, with a characteristic side chain. This compound selectively inhibited gluconeogenesis of rat pri...

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Veröffentlicht in:Journal of antibiotics 2005-07, Vol.58 (7), p.452-455
Hauptverfasser: Ohtsu, Yoshihiro, Sasamura, Hiromi, Shibata, Toshihiro, Hino, Motohiro, Nakajima, Hidenori
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Animals
Blood Glucose - drug effects
Cells, Cultured
Diabetes Mellitus, Experimental - drug therapy
Gluconeogenesis - drug effects
Hepatocytes - drug effects
Hepatocytes - metabolism
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Male
Mice
Mice, Inbred C57BL
Naphthalenes - administration & dosage
Naphthalenes - pharmacology
Naphthalenes - therapeutic use
Rats
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Zusammenfassung:The novel gluconeogenesis inhibitor FR225654, isolated from the culture broth of Phoma sp. No. 00144, has an unique structure that consists of a highly oxygenated trans-decalin ring and a beta-keto-enol, with a characteristic side chain. This compound selectively inhibited gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in several in vivo mouse models.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2005.59