Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process

Oxidative modification alters the function of proteins and is thought to play an important role in the decline of cellular function during aging process. In the present study, we have evaluated the levels of oxidant production, protein oxidation, reduced and oxidized glutathione in young, middle aged and aged rats. The animals were divided into six groups, each group consisting of six animals each. Groups I and II were young rats, Groups III and IV were middle-aged rats and Groups V and VI were aged rats. Groups II, IV and VI were treated with carnitine (300 mg/kg bw) and Dl-alpha-Lipoic acid (100 mg/kg bw) for 28 days. Statistical significance was carried out using ANOVA. There was a significant reduction in the levels of reduced glutathione and Redox ratio (P