Effects of the shape of coronary arteries on the presence, extent, and severity of their disease

It is now known that a C-shaped right coronary artery (RCA) (C-RCA) is associated with more atherosclerotic disease than a sigma-shaped RCA (S-RCA). This study was designed to investigate the relationship between the shape of the RCA and the presence, extent, and severity of coronary artery disease (CAD) in all coronary arteries. Two hundred and forty-five patients were divided into C-RCA (group 1, n = 161) and S-RCA (group 2, n = 84) groups. The vessel score, extent score, and Gensini score were higher in group 1 than in group 2 (P < 0.001 for all comparisons). In multivariate analyses, age (P = 0.001), male sex (P < 0.001), smoking (P = 0.002), and C-RCA (P < 0.001) were independent predictors of significant CAD (presence of at least one lesion causing at least >50% stenosis). Multiple linear regression analysis to predict vessel score identified C-RCA (P < 0.001), age (P = 0.004), and male sex (P = 0.020), to predict extent score identified C-RCA (P < 0.001), age (P = 0.005), and male sex (P = 0.003), and to predict Gensini score identified C-RCA (P < 0.001), male sex (P = 0.009), and dyslipidemia (P = 0.049) as independently associated variables. Sensitivity and specificity of C-RCA for detecting significant CAD were 79% and 46%, respectively. This study showed that C-RCA was an independent predictor of significant CAD, which was independently associated with vessel score, extent score, and Gensini score. However, it was not clinically useful, because it was not specific or sensitive enough to identify patients with significant CAD.