In Vivo Wound-Healing Activity of Oleanolic Acid Derived from the Acid Hydrolysis of Anredera diffusa

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The hi...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-06, Vol.69 (6), p.978-979
Hauptverfasser:	Moura-Letts, G, Villegas, L.F, Marçalo, A, Vaisberg, A.J, Hammond, G.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anredera difffusa Basellaceae Biological and medical sciences Caryophyllaceae - chemistry General pharmacology hydrolysis Medical sciences medicinal plants Medicine, Traditional Mice Molecular Structure oleanolic acid Oleanolic Acid - analogs & derivatives Oleanolic Acid - chemistry Oleanolic Acid - isolation & purification Oleanolic Acid - pharmacology Peru Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry tissue repair traditional medicine Wound Healing - drug effects
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Zusammenfassung:	Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 microg of oleanolic acid per gram of body weight.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0601152