Models of Putative (AH)G(AH)G Nucleobase Quartets

Models of Putative (AH)G(AH)G Nucleobase Quartets

Mispairs of protonated adenine and guanine (or hypoxanthine), AH+anti G/Hxsyn, can associate in various ways to give mixed purine quartets (see picture) as demonstrated by X‐ray crystallography and ab initio calculations. The planar structure of such quartets implies that akin to established purine...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-09, Vol.44 (35), p.5670-5674
Hauptverfasser: Amo-Ochoa, Pilar, Sanz Miguel, Pablo J., Lax, Patrick, Alonso, Inés, Roitzsch, Michael, Zamora, Félix, Lippert, Bernhard
Format: Artikel
Sprache:eng
Schlagworte:
Adenine - chemistry
Crystallography, X-Ray
DNA structures
Guanine - chemistry
Hydrogen Bonding
hydrogen bonds
Models, Molecular
nucleobases
purine quartets
Xanthine - chemistry
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Beschreibung
Zusammenfassung:Mispairs of protonated adenine and guanine (or hypoxanthine), AH+anti G/Hxsyn, can associate in various ways to give mixed purine quartets (see picture) as demonstrated by X‐ray crystallography and ab initio calculations. The planar structure of such quartets implies that akin to established purine nucleobase quartets, these quartets could also play a role in natural DNA structures.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500896