Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior

Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior

Various functions are integrated into a single chromosome molecule. The genomic approach (ChIP‐chip) we introduce here is a very powerful tool to study dynamic changes of the structure and function of the chromosome at the level of protein‐DNA interaction as precisely as possible without prejudice o...

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Veröffentlicht in:Methods in Enzymology 2006, Vol.409, p.389-410
Hauptverfasser: Katou, Yuki, Kaneshiro, Kiyofumi, Aburatani, Hiroyuki, Shirahige, Katsuhiko
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Chromosomes
DNA Primers
DNA Replication
Genomics
Oligonucleotide Array Sequence Analysis
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container_issue
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container_title Methods in Enzymology
container_volume 409
creator Katou, Yuki
Kaneshiro, Kiyofumi
Aburatani, Hiroyuki
Shirahige, Katsuhiko
description Various functions are integrated into a single chromosome molecule. The genomic approach (ChIP‐chip) we introduce here is a very powerful tool to study dynamic changes of the structure and function of the chromosome at the level of protein‐DNA interaction as precisely as possible without prejudice or bias. This technology opens up the way to understand how local protein‐protein or protein‐DNA interactions lead to the dynamic changes of chromosome structure and how various chromosomal functions are connected to make a network for the faithful maintenance of the genome.
doi_str_mv 10.1016/S0076-6879(05)09023-3
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subjects Base Sequence
Chromosomes
DNA Primers
DNA Replication
Genomics
Oligonucleotide Array Sequence Analysis
title Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior
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