Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior

Various functions are integrated into a single chromosome molecule. The genomic approach (ChIP‐chip) we introduce here is a very powerful tool to study dynamic changes of the structure and function of the chromosome at the level of protein‐DNA interaction as precisely as possible without prejudice or bias. This technology opens up the way to understand how local protein‐protein or protein‐DNA interactions lead to the dynamic changes of chromosome structure and how various chromosomal functions are connected to make a network for the faithful maintenance of the genome.