Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world?
Background: Predictive factors of childhood asthma for favorable prognosis may differ between populations where a variety of genetic and environmental factors are present. Objectives: To document the factors predicting disease persistence in early adulthood in Turkey. Methods: An outpatient cohor...
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| Veröffentlicht in: | Allergy (Copenhagen) 2006-07, Vol.61 (7), p.869-877 |
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| container_title | Allergy (Copenhagen) |
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| creator | Sekerel, B. E. Civelek, E. Karabulut, E. Yildirim, S. Tuncer, A. Adalioglu, G. |
| description | Background: Predictive factors of childhood asthma for favorable prognosis may differ between populations where a variety of genetic and environmental factors are present.
Objectives: To document the factors predicting disease persistence in early adulthood in Turkey.
Methods: An outpatient cohort (n = 115) with a mean follow‐up duration of 11.4 ± 0.2 years was evaluated. Complete remission was defined as no asthma symptoms, no use of controller medication, no airflow limitation and no airway hyper‐responsiveness, and clinical remission as no symptoms and no use of controller medication, within the past year.
Results: The mean ages during referral and at the final visit were 5.8 ± 0.2 and 17.1 ± 0.2 years, respectively. Thirty‐one (27%) were in complete remission, and a further 30 (26%) in clinical remission. In multivariate logistic models, diminished airflow [forced expiratory volume in 1 s (FEV1) |
| doi_str_mv | 10.1111/j.1398-9995.2006.01082.x |
| format | Article |
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Objectives: To document the factors predicting disease persistence in early adulthood in Turkey.
Methods: An outpatient cohort (n = 115) with a mean follow‐up duration of 11.4 ± 0.2 years was evaluated. Complete remission was defined as no asthma symptoms, no use of controller medication, no airflow limitation and no airway hyper‐responsiveness, and clinical remission as no symptoms and no use of controller medication, within the past year.
Results: The mean ages during referral and at the final visit were 5.8 ± 0.2 and 17.1 ± 0.2 years, respectively. Thirty‐one (27%) were in complete remission, and a further 30 (26%) in clinical remission. In multivariate logistic models, diminished airflow [forced expiratory volume in 1 s (FEV1) <80%vs≥80%] at the initial lung function test predicted current diminished airflow (8.422; 2.202–32.206) (odds ratio; 95% confidence interval), and presence of obstructive pattern (FEV1/forced vital capacity (FVC) <80%vs≥80%) predicted current obstructive pattern (29.333; 3.022–284.724). Furthermore, female gender appeared to predict persistence of asthma symptoms (3.330; 1.250–8.333) and absence of clinical remission (2.398; 1.038–5.254); eosinophilia predicted persistence of symptoms (4.271; 1.080–16.889) and presence of airway hyper‐responsiveness (3.723; 1.129–12.278).
Conclusions: Diminished airflow, female gender and eosinophilia appear to predict an adverse outcome of childhood asthma, supporting the concept that variability may exist between populations.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.2006.01082.x</identifier><identifier>PMID: 16792587</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; adulthood ; Allergic diseases ; asthma ; Asthma - epidemiology ; Asthma - etiology ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Hyperreactivity - diagnosis ; Bronchoconstrictor Agents - pharmacology ; Child ; Developing Countries ; Eosinophils - immunology ; Female ; Forced Expiratory Volume ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; gender ; Humans ; Immunoglobulin E - blood ; Immunopathology ; Leukocyte Count ; Male ; Medical sciences ; Methacholine Chloride - pharmacology ; prognostic factors ; Retrospective Studies ; Risk Factors ; Sex Factors ; Skin Tests ; Spirometry ; Turkey ; Vital Capacity</subject><ispartof>Allergy (Copenhagen), 2006-07, Vol.61 (7), p.869-877</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4632-e0e42428d47b752fc8ce2ba26e2347ca462053ef294f98920e74b18e3ad920a3</citedby><cites>FETCH-LOGICAL-c4632-e0e42428d47b752fc8ce2ba26e2347ca462053ef294f98920e74b18e3ad920a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.2006.01082.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.2006.01082.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17848399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16792587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekerel, B. E.</creatorcontrib><creatorcontrib>Civelek, E.</creatorcontrib><creatorcontrib>Karabulut, E.</creatorcontrib><creatorcontrib>Yildirim, S.</creatorcontrib><creatorcontrib>Tuncer, A.</creatorcontrib><creatorcontrib>Adalioglu, G.</creatorcontrib><title>Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world?</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background: Predictive factors of childhood asthma for favorable prognosis may differ between populations where a variety of genetic and environmental factors are present.
Objectives: To document the factors predicting disease persistence in early adulthood in Turkey.
Methods: An outpatient cohort (n = 115) with a mean follow‐up duration of 11.4 ± 0.2 years was evaluated. Complete remission was defined as no asthma symptoms, no use of controller medication, no airflow limitation and no airway hyper‐responsiveness, and clinical remission as no symptoms and no use of controller medication, within the past year.
Results: The mean ages during referral and at the final visit were 5.8 ± 0.2 and 17.1 ± 0.2 years, respectively. Thirty‐one (27%) were in complete remission, and a further 30 (26%) in clinical remission. In multivariate logistic models, diminished airflow [forced expiratory volume in 1 s (FEV1) <80%vs≥80%] at the initial lung function test predicted current diminished airflow (8.422; 2.202–32.206) (odds ratio; 95% confidence interval), and presence of obstructive pattern (FEV1/forced vital capacity (FVC) <80%vs≥80%) predicted current obstructive pattern (29.333; 3.022–284.724). Furthermore, female gender appeared to predict persistence of asthma symptoms (3.330; 1.250–8.333) and absence of clinical remission (2.398; 1.038–5.254); eosinophilia predicted persistence of symptoms (4.271; 1.080–16.889) and presence of airway hyper‐responsiveness (3.723; 1.129–12.278).
Conclusions: Diminished airflow, female gender and eosinophilia appear to predict an adverse outcome of childhood asthma, supporting the concept that variability may exist between populations.</description><subject>Adolescent</subject><subject>adulthood</subject><subject>Allergic diseases</subject><subject>asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - diagnosis</subject><subject>Bronchoconstrictor Agents - pharmacology</subject><subject>Child</subject><subject>Developing Countries</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>gender</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Chloride - pharmacology</subject><subject>prognostic factors</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Skin Tests</subject><subject>Spirometry</subject><subject>Turkey</subject><subject>Vital Capacity</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEGP1CAUx4nRuLOrX8Fw0VsrBdrCwZjJRl2TSbzsnTDwcBiZUnkdd-fb2-5M3Ktc4PF-_wf5EUIbVjfz-rivG6FVpbVua85YV7OGKV4_viCrf42XZDXftpVshboi14h7xljPNXtNrpqu17xV_Yqc1gVoifiLBuumXJDmQN0uJr_L2VOL0-5g6VjARzfF4Sf1EcEi0BEKRpxgcEDjQMGWdKLWH9P0FPQxBCgwTEtz2gH18AdSHpcRD7kk__kNeRVsQnh72W_I_dcv97d31ebHt--3603lZCd4BQwkl1x52W_7lgenHPCt5R1wIXtnZcdZKyBwLYNWmjPo5bZRIKyfCytuyIfz2LHk30fAyRwiOkjJDpCPaDrVdi1XagbVGXQlIxYIZizxYMvJNMws1s3eLHLNItcs1s2TdfM4R99d3jhuD-CfgxfNM_D-Alh0NoViBxfxmeuVVELrmft05h5igtN_f8CsN5vlJP4CUt2fdg</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Sekerel, B. E.</creator><creator>Civelek, E.</creator><creator>Karabulut, E.</creator><creator>Yildirim, S.</creator><creator>Tuncer, A.</creator><creator>Adalioglu, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world?</title><author>Sekerel, B. E. ; Civelek, E. ; Karabulut, E. ; Yildirim, S. ; Tuncer, A. ; Adalioglu, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4632-e0e42428d47b752fc8ce2ba26e2347ca462053ef294f98920e74b18e3ad920a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>adulthood</topic><topic>Allergic diseases</topic><topic>asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity - diagnosis</topic><topic>Bronchoconstrictor Agents - pharmacology</topic><topic>Child</topic><topic>Developing Countries</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>gender</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Chloride - pharmacology</topic><topic>prognostic factors</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Skin Tests</topic><topic>Spirometry</topic><topic>Turkey</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sekerel, B. E.</creatorcontrib><creatorcontrib>Civelek, E.</creatorcontrib><creatorcontrib>Karabulut, E.</creatorcontrib><creatorcontrib>Yildirim, S.</creatorcontrib><creatorcontrib>Tuncer, A.</creatorcontrib><creatorcontrib>Adalioglu, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekerel, B. E.</au><au>Civelek, E.</au><au>Karabulut, E.</au><au>Yildirim, S.</au><au>Tuncer, A.</au><au>Adalioglu, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world?</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2006-07</date><risdate>2006</risdate><volume>61</volume><issue>7</issue><spage>869</spage><epage>877</epage><pages>869-877</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>Background: Predictive factors of childhood asthma for favorable prognosis may differ between populations where a variety of genetic and environmental factors are present.
Objectives: To document the factors predicting disease persistence in early adulthood in Turkey.
Methods: An outpatient cohort (n = 115) with a mean follow‐up duration of 11.4 ± 0.2 years was evaluated. Complete remission was defined as no asthma symptoms, no use of controller medication, no airflow limitation and no airway hyper‐responsiveness, and clinical remission as no symptoms and no use of controller medication, within the past year.
Results: The mean ages during referral and at the final visit were 5.8 ± 0.2 and 17.1 ± 0.2 years, respectively. Thirty‐one (27%) were in complete remission, and a further 30 (26%) in clinical remission. In multivariate logistic models, diminished airflow [forced expiratory volume in 1 s (FEV1) <80%vs≥80%] at the initial lung function test predicted current diminished airflow (8.422; 2.202–32.206) (odds ratio; 95% confidence interval), and presence of obstructive pattern (FEV1/forced vital capacity (FVC) <80%vs≥80%) predicted current obstructive pattern (29.333; 3.022–284.724). Furthermore, female gender appeared to predict persistence of asthma symptoms (3.330; 1.250–8.333) and absence of clinical remission (2.398; 1.038–5.254); eosinophilia predicted persistence of symptoms (4.271; 1.080–16.889) and presence of airway hyper‐responsiveness (3.723; 1.129–12.278).
Conclusions: Diminished airflow, female gender and eosinophilia appear to predict an adverse outcome of childhood asthma, supporting the concept that variability may exist between populations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16792587</pmid><doi>10.1111/j.1398-9995.2006.01082.x</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent adulthood Allergic diseases asthma Asthma - epidemiology Asthma - etiology Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - diagnosis Bronchoconstrictor Agents - pharmacology Child Developing Countries Eosinophils - immunology Female Forced Expiratory Volume Fundamental and applied biological sciences. Psychology Fundamental immunology gender Humans Immunoglobulin E - blood Immunopathology Leukocyte Count Male Medical sciences Methacholine Chloride - pharmacology prognostic factors Retrospective Studies Risk Factors Sex Factors Skin Tests Spirometry Turkey Vital Capacity |
| title | Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world? |
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