Synthesis of (−)-Amphidinolide K Fragment C9−C22

Synthesis of (−)-Amphidinolide K Fragment C9−C22

The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (−)-amphidinolide K (1) has been achieved from synthons C9−C14 (3) and C15−C22 (4), which have both been prepared from glutamic acid in good overall yields.

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Veröffentlicht in:Organic letters 2005-09, Vol.7 (19), p.4083-4086
Hauptverfasser: Andreou, Thanos, Costa, Anna M, Esteban, Laia, Gonzàlez, Lluïsa, Mas, Gemma, Vilarrasa, Jaume
Format: Artikel
Sprache:eng
Schlagworte:
Macrolides - chemical synthesis
Macrolides - chemistry
Molecular Structure
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Zusammenfassung:The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (−)-amphidinolide K (1) has been achieved from synthons C9−C14 (3) and C15−C22 (4), which have both been prepared from glutamic acid in good overall yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol051200o