Expression of the IGF system in human adrenal tissues from early infancy to late puberty : Implications for the development of adrenarche

IGF-1, IGF-2, and type 1 IGF receptor (IGF-R1) mRNA expression and immunolocalization and cell proliferation index were studied in human adrenals from early infancy to late puberty. Adrenals were obtained from transplantation donors or from necropsies of endocrinologically normal subjects. Subjects...

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Veröffentlicht in:	Pediatric research 2005-09, Vol.58 (3), p.451-458
Hauptverfasser:	BAQUEDANO, Maria Sonia, BERENSZTEIN, Esperanza, SARACO, Nora, DORN, Gabriela Vanesa, DE DAVILA, Maria T, RIVAROLA, Marco A, BELGOROSKY, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Glands - growth & development Adrenal Glands - metabolism Adrenarche Biological and medical sciences Child Child, Preschool General aspects Humans Infant Infant, Newborn Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor II - genetics Medical sciences Receptor, IGF Type 1 - genetics RNA, Messenger - genetics
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Zusammenfassung:	IGF-1, IGF-2, and type 1 IGF receptor (IGF-R1) mRNA expression and immunolocalization and cell proliferation index were studied in human adrenals from early infancy to late puberty. Adrenals were obtained from transplantation donors or from necropsies of endocrinologically normal subjects. Subjects were divided into three age groups: group 1,
ISSN:	0031-3998 1530-0447
DOI:	10.1203/01.pdr.0000179392.59060.93