BURKHOLDERIA GLADIOLI OSTEOMYELITIS IN ASSOCIATION WITH CHRONIC GRANULOMATOUS DISEASE: CASE REPORT AND REVIEW

We describe a case of insidious small bone osteomyelitis and soft tissue abscess with Burkholderia gladioli in a 6-year-old Caucasian boy with chronic granulomatous disease. DNA sequencing of the 16S ribosomal RNA gene confirmed the bacterial identification. Clinical cure was achieved with a combina...

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Veröffentlicht in:	The Pediatric infectious disease journal 2005-09, Vol.24 (9), p.837-839
Hauptverfasser:	Boyanton, Bobby L, Noroski, Lenora M, Reddy, Hari, Dishop, Megan K, Hicks, M John, Versalovic, James, Moylett, Edina H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Burkholderia gladioli - isolation & purification Burkholderia Infections - complications Burkholderia Infections - diagnosis Burkholderia Infections - drug therapy Child Follow-Up Studies Granulomatous Disease, Chronic - complications Granulomatous Disease, Chronic - diagnosis Granulomatous Disease, Chronic - genetics Hematologic and hematopoietic diseases Human bacterial diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Osteomyelitis - complications Osteomyelitis - diagnosis Osteomyelitis - drug therapy Other diseases. Hematologic involvement in other diseases Risk Assessment RNA, Ribosomal, 16S - analysis RNA, Ribosomal, 16S - genetics Severity of Illness Index Treatment Outcome
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Zusammenfassung:	We describe a case of insidious small bone osteomyelitis and soft tissue abscess with Burkholderia gladioli in a 6-year-old Caucasian boy with chronic granulomatous disease. DNA sequencing of the 16S ribosomal RNA gene confirmed the bacterial identification. Clinical cure was achieved with a combination of antimicrobial therapy and surgical debridement. A review of infections caused by Burkholderia spp., other than Burkholderia cepacia complex, in pediatric patients with chronic granulomatous disease is provided.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/01.inf.0000177285.44374.dc