Changes in ultrastructure of lung aerohematic barrier and blood gas indices in long term exercise

The aim of the study was to find out the key manifestations of reorganization of lung aerohematic barrier (AB) components (cellular and tissue) in the process of a prolonged physical exercise, taking into account changes in the indices of blood acid-basic balance (ABB). The physical exercise (running in treadbane, 2 hours daily, rotation frequency -- 19 r/min) was reproduced in white laboratory rats, body weight 180.0-200.0 gr. Pulmonary tissue specimens were collected after 3, 7, 10-60 days. ABB was determinate in capillary blood samples with the apparatus "Microastrup". The materials were used for general histological, electronmicroscopic and morphometric examination. The digital findings were treated with MS Excel. The earliest informative sign of appearance of surfactant dependent atelectasis and alveolar epithelium is trombocytes stasis in interaalveolar capillary lumens with plasma insudation into the depth of aerohematic barrier that is negatively reflected on the processes of ventilation and gas exchange with the tendency of development of hypercapnia and metabolic acidosis to the end (50-60 days) of the experiment. The structural basis of this state is collagen formation in aerohematic barrier tissue component.