Diphenylprolinol Methyl Ether:  A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

Diphenylprolinol Methyl Ether:  A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95−99% ee) and significantly lower catalyst loadings than have been typical in this arena.

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Veröffentlicht in:Organic letters 2005-09, Vol.7 (19), p.4253-4256
Hauptverfasser: Chi, Yonggui, Gellman, Samuel H
Format: Artikel
Sprache:eng
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Zusammenfassung:Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95−99% ee) and significantly lower catalyst loadings than have been typical in this arena.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0517729